Centre of Research Excellence for Probe-Net: The Progression of Barrett's Esophagus to Cancer Network

Grant number: 1040947 | Funding period: 2013 - 2017

Completed

Abstract

This application brings together the seven major research teams in Australia with expertise in oesophageal neoplasia to form a multi-state, multi-disciplinary Centre for Research Excellence. All of the nodes have worked together collaboratively for the past 4 years, pooling their expertise in surgery, gastroenterology, endoscopy, epidemiology, biostatistics, basic science, health policy and translational research. Our vision is to develop evidence-based strategies for reducing the burden of oesophageal neoplasia.

Related publications (7)

Inhibiting system xC − and glutathione biosynthesis–a potential Achilles' heel in mutant-p53 cancers

NJ Clemons, DS Liu, CP Duong, WA Phillips

2017-09-03

Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need..

Inhibiting the system xC - /glutathione axis selectively targets cancers with mutant-p53 accumulation

DS Liu, CP Duong, S Haupt, KG Montgomery, CM House, WJ Azar, HB Pearson, OM Fisher, M Read, GR Guerra, Y Haupt, C Cullinane, KG Wiman, L Abrahmsen, WA Phillips, NJ Clemons

2017-03-28

TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and p..

The prognostic value of TP53 mutations in oesophageal adenocarcinoma: A systematic review and meta-analysis

OM Fisher, SJ Lord, D Falkenback, NJ Clemons, GD Eslick, RV Lord

2017-03-01

Objective To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) a..

The Genetics of Barrett’s Esophagus: A Familial and Population-Based Perspective

H To, NJ Clemons, CP Duong, AH Trainer, WA Phillips

2016-07-01

Barrett’s esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC..

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts

M Read, D Liu, CP Duong, C Cullinane, WK Murray, CM Fennell, J Shortt, D Westerman, P Burton, NJ Clemons, WA Phillips

2016-01-01

Background: Recently, there has been an increase in the availability of targeted molecular therapies for cancer treatment. The app..

Preclinical models of esophageal adenocarcinoma for drug development

DS Liu, CP Duong, WA Phillips, NJ Clemons

2016-01-01

The advent of multi-omic profiling of tumors, together with the increasing affordability of high-throughput drug screening program..

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

DSH Liu, M Read, C Cullinane, WJ Azar, CM Fennell, KG Montgomery, S Haupt, Y Haupt, KG Wiman, CP Duong, NJ Clemons, WA Phillips

2015-07-17

University of Melbourne Researchers

Wayne Phillips